Peptides — Dr. Khavinson’s Peptide Research
Presentation by: Dan Kronz
Reviewed by: Kritika Pathak
Dr. Vladimir Khavinson has blazed the trail for peptide research over the past 30 years, showing that peptides are a powerful tool for improving the quality of life in old age and lengthening life as well. He found that peptides found in various organs throughout the body are very beneficial in extending and improving life. It is theorized that humans could have an extra 30% to 40% longer life expectancy than we are currently living up to (70 to 75 years). [1] He has found a wide range of peptide therapies, such as treating aging mechanisms like telomere shortening, heterochromatization, diabetes mellitus, nerve degradation and many more. His work could be one of the major keys to unlocking longer life.
Further studies:
1. Conduct human studies and look at aging markers over a lifetime
2. Look into the mechanism behind cortagen and the pineal peptide
3. Investigate the possible increase in tumors by the activation of telomerase in cells
4. Investigate the possible combination of Cortagen and Metformin on Diabetic subjects
References:
[1] Weindruch R, Walford RL, Fligiel S, Guthrie D. The retardation of aging in mice by dietary restriction: longevity, cancer, immunity, and lifetime energy intake. J Nutr. 1986;116(4):641-654. doi:10.1093/jn/116.4.641
[2] Lezhava, T. (1984). Heterochromatinization as a key factor in aging. Mechanisms of Ageing and Development, 28(2-3), 279-287. doi:10.1016/0047-6374(84)90028-9
[3] Riadnova I.Yu., Shataeva L.K., Khavinson V. Kh. DNA-protein interaction studied in model systems // Polymer Science, Ser. A. – 2000. – V. 42, № 5. – P. 551-556.(Rus)
[4] Vinogradova IA, Bukalev AV, Zabezhinski MA, Semenchenko AV, Khavinson VKh, Anisimov VN. Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes. Bull Exp Biol Med. 2007;144(6):825-830. doi:10.1007/s10517-007-0441-z
[5] Peptide regulation of aging. (n.d.). Retrieved July 04, 2020, from https://khavinson.info/research/pepti...
[6] López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194–1217. https://doi.org/10.1016/j.cell.2013.0...
[7] Khavinson VKh, Gapparov MM, Sharanova NE, Vasilyev AV, Ryzhak GA. Study of biological activity of Lys-Glu-Asp-Trp-NH2 endogenous tetrapeptide. Bull Exp Biol Med. 2010;149(3):351-353. doi:10.1007/s10517-010-0944-x
[8] Turchaninova, L. N., Kolosova, L. I., Malinin, V. V., Moiseeva, A. B., Nozdrachev, A. D., & Khavinson, V. K. (2000). Effect of tetrapeptide cortagen on regeneration of sciatic nerve. Bulletin of Experimental Biology and Medicine, 130(6), 1172-1174. doi:10.1007/bf02682018
[9] Verdú, E., Ceballos, D., Vilches, J. J., & Navarro, X. (2000). Influence of aging on peripheral nerve function and regeneration. Journal of the peripheral nervous system: JPNS, 5(4), 191–208. https://doi.org/10.1046/j.1529-8027.2...