Psilocybin

Presentation by Lena Hull

Peer-reviewed by Kacee Doan & Christopher Timbreza

Introduction:

Psilocybin has been present in the scientific community since the 1960s, but only recently has been considered for treatment of addiction. Swiss chemist Albert Hoffman was the first to extract psilocybin from Psilocybe mexicana in 1959 (Hoffman et al., 1959). Soon after this, in 1960, Timothy Leary and Richard Alpert conducted the controversial Harvard Psilocybin Project. This project was not entirely scientific; they tested 175 students, of which the majority said that they had learned something about themselves after taking psilocybin, and wanted to take it again. Later, Leary conducted tests on prisoners in Concord by giving them psilocybin then collecting qualitative data, and found a massive success rate. Prisoners were said to have very positive, “religious” experiences that inspired them to reform, something the prison system never did for them. Because of this, Learly proposed the use of psilocybin in the federal penal system as a sort of therapy but was denied (Leaman, 2011).

References

Blough, B. E., Landavazo, A., Decker, A. M., Partilla, J. S., Baumann, M. H., & Rothman, R. B. (2014). Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes. Psychopharmacology, 231(21), 4135-4144. doi:10.1007/s00213-014-3557-7

Bogenschutz, M. P., Forcehimes, A. A., Pommy, J. A., Wilcox, C. E., Barbosa, P., & Strassman, R. J. (2015). Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study. Journal of Psychopharmacology, 29(3), 289-299. doi:10.1177/0269881114565144

Bogenschutz, M. P. (2016). It’s time to take psilocybin seriously as a possible treatment for substance use disorders. The American Journal of Drug and Alcohol Abuse, 43(1), 4–6. doi: 10.1080/00952990.2016.1200060

Breakthrough Therapy. (2018, January 4). Retrieved June 17, 2020, from https://www.fda.gov/patients/fast-track-breakthrough-therapy-accelerated-approval-priority-review/breakthrough-therapy

Drugs of Abuse [PDF]. (2017). Washington, DC: Drug Enforcement Administration.

Gabay, M. (2013). The Federal Controlled Substances Act: Schedules and Pharmacy Registration. Hospital Pharmacy, 48(6), 473–474. doi: 10.1310/hpj4806-473

Hale, V. (n.d.). The FDA and Psychedelic Drug Development: Working Together to Make Medicines. Retrieved June 17, 2020, from https://maps.org/news/bulletin/articles/439-bulletin-spring-2020/8129-the-fda-and-psychedelic-drug-development-working-together-to-make-medicines

Hofmann, A., Heim, R., Brack, A., Kobel, H., Frey, A., Ott, H., … Troxler, F. (1959). Psilocybin und Psilocin, zwei psychotrope Wirkstoffe aus mexikanischen Rauschpilzen. Helvetica Chimica Acta, 42(5), 1557–1572. doi: 10.1002/hlca.19590420518

Johnson, M. W., Garcia-Romeu, A., & Griffiths, R. R. (2016). Long-term follow-up of psilocybin-facilitated smoking cessation. The American Journal of Drug and Alcohol Abuse, 43(1), 55-60. doi:10.3109/00952990.2016.1170135

Kometer, M., Cahn, B. R., Andel, D., Carter, O. L., & Vollenweider, F. X. (2011). The 5-HT2A/1A Agonist Psilocybin Disrupts Modal Object Completion Associated with Visual Hallucinations. Biological Psychiatry, 69(5), 399-406. doi:10.1016/j.biopsych.2010.10.002

Leaman, K. (2011, November 4). PDF. West Lafayette.

Madsen, M. K., Fisher, P. M., Stenbæk, D. S., Kristiansen, S., Burmester, D., Lehel, S., . . . Knudsen, G. M. (2020). A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding. European Neuropsychopharmacology, 33, 71-80. doi:10.1016/j.euroneuro.2020.02.001

Multidisciplinary Association for Psychedelic Studies. (2020). Retrieved September 08, 2020, from https://maps.org/

Osborne, E. (n.d.). My Struggles, Depression, and My Work With Psilocybin [Web log post]. Retrieved June 18, 2020, from https://www.mycomeditations.com/my-struggles-depression-and-my-work-with-psilocybin/

Passie, T., Seifert, J., Schneider, U., & Emrich, H. M. (2002). The pharmacology of psilocybin. Addiction Biology, 7(4), 357-364. doi:10.1080/1355621021000005937

Petri, G., Expert, P., Turkheimer, F., Carhart-Harris, R., Nutt, D., Hellyer, P. J., & Vaccarino, F. (2014). Homological scaffolds of brain functional networks. Journal of The Royal Society Interface, 11(101). doi:10.1098/rsif.2014.0873

Porter, D. (2020, June 18). [Facebook comment from Facebook group Psychadelic Society].

Psychedelic Integration List. (n.d.). Retrieved June 18, 2020, from https://integration.maps.org/

Simoneaux, R. (2019). The Potential of Psilocybin Administration in Terminal Cancer Patients. Oncology Times, 41(13), 14-15. doi:10.1097/01.cot.0000574916.46844.cf

Staff. (n.d.). Retrieved June 18, 2020, from https://maps.org/about/staff