Mesenchymal Stem Cells

Presentation by Soumyaa Thakur

Peer reviewed by Jillian Pontanares & Vi Lam

Introduction:

The pandemic that took everyone by shock taught the entire world about the importance of research. In this short video, I explain the use of Mesenchymal Stem Cells (MSC) as a potential therapeutic measure to battle the SARS-CoV-2 virus. MSCs form an easily available and well-researched aspect that has shown promising effects previously. This video explains, in-depth, the benefits of using MSCs as a therapeutic measure and also the mode of action MSCs in the body of an infected individual.

Future Research

More trials need to be carried out to confirm the therapeutic effects of the stem cells. Trial subjects must be observed for a long period of time to check for the occurrence long term effects.

 

References

https://cryobank.ua/en/news-en/how-stem-cells-combat-coronavirus/

https://www.europeanpharmaceuticalreview.com/news/120258/experimental-stem-cell-therapy-trial-for-covid-19-initiated/

https://www.technologynetworks.com/biopharma/articles/exploring-the-utility-of-stem-cell-therapy-for-covid-19-334068

Ludwig, S., & Zarbock, A. (2020). Coronaviruses and SARS-CoV-2: A Brief Overview. Anesthesia & Analgesia, 131(1), 93-96. doi: 10.1213/ane.0000000000004845  

European Society of cardiology. (2020). ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic, 1–115.

Rajarshi, K., Chatterjee, A., & Ray, S. (2020). Combating COVID-19 with mesenchymal stem cell therapy. Biotechnology Reports, 26, e00467. https://doi.org/10.1016/j.btre.2020.e00467

Sengupta V, Sengupta S, Lazo A, Woods P, Nolan A, Bremer N. Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19. Stem Cells Dev. 2020;29(12):747-754. doi:10.1089/scd.2020.0080

Moll G, Drzeniek N, Kamhieh-Milz J, Geissler S, Volk HD, Reinke P. MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy. Front Immunol. 2020;11:1091. Published 2020 May 19. doi:10.3389/fimmu.2020.01091.

Bamba C, Singh SP, Choudhury S. Can mesenchymal stem cell therapy be the interim management of COVID-19?. Drug Discov Ther. 2020;14(3):139-142. doi:10.5582/ddt.2020.03032.

Cao X. COVID-19: immunopathology and its implications for therapy. Nat Rev Immunol. 2020;20(5):269-270. doi:10.1038/s41577-020-0308-3.

Yen BL, Yen ML, Wang LT, Liu KJ, Sytwu HK. Current status of mesenchymal stem cell therapy for immune/inflammatory lung disorders: Gleaning insights for possible use in COVID-19 [published online ahead of print, 2020 Jun 11]. Stem Cells Transl Med. 2020;10.1002/sctm.20-0186. doi:10.1002/sctm.20-0186