Presentation by Ben Kronz
Peer-reviewed by Kritika Pathak
Angiogenesis and BPC-157 introduction
BPC-157 has been shown to have a broad effect on the body, it has been shown to be an anti-ulcer, alleviates inflammatory bowel syndrome, stimulates tendon and tissue healing, promotes angiogenesis, and even has an effect on brain health. Angiogenesis, which is the growth of new capillaries in the body tissues, could play an important role in the extension and improvement of life. Research has shown that as we age angiogenesis is important for heart health and stroke recovery. BPC-157 is one way that we can upregulate angiogenesis as we age!
Further research
Could BPC-157 be used to increase heart health by capillary balance?
How does angiogenesis help with vascular dementia?
Could human studies be done on BPC-157 on the rate of tissue healing?
Could long term supplementation of BPC-157 cause too much angiogenesis and cardiovascular issues?
References:
Myocardial ischemia - Symptoms and causes. (2019, April 6). Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/myocardial-ischemia/symptoms-causes/syc-20375417
Folkman, J. (1984). Angiogenesis. Developments in Cardiovascular Medicine Biology of Endothelial Cells, 412-428. doi:10.1007/978-1-4613-2825-4_42
Yousufuddin, M., & Young, N. (2019). Aging and ischemic stroke. Aging, 11(9), 2542–2544. https://doi.org/10.18632/aging.101931
Adair TH, Montani JP. Angiogenesis. San Rafael (CA): Morgan & Claypool Life Sciences; 2010. Chapter 1, Overview of Angiogenesis. Available from: https://www.ncbi.nlm.nih.gov/books/NBK53238/
Isner, J. M., & Losordo, D. W. (1999). Therapeutic angiogenesis for heart failure. Nature Medicine, 5(5), 491-492. doi:10.1038/8374
Lähteenvuo, J., & Rosenzweig, A. (2012). Effects of Aging on Angiogenesis. Circulation Research, 110(9), 1252-1264. doi:10.1161/circresaha.111.246116
Novinscak T, Brcic L, Staresinic M, et al. Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat. Surg Today. 2008;38(8):716-725. doi:10.1007/s00595-007-3706-2
The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks. Journal of Physiology-Paris, 91(3-5), 139-149. doi:10.1016/s0928-4257(97)89478-8
Siemerink, M. J., Klaassen, I., Vogels, I. M., Griffioen, A. W., Van Noorden, C. J., & Schlingemann, R. O. (2012). CD34 marks angiogenic tip cells in human vascular endothelial cell cultures. Angiogenesis, 15(1), 151–163. https://doi.org/10.1007/s10456-011-9251-z
Novinscak T, Brcic L, Staresinic M, et al. Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat. Surg Today. 2008;38(8):716-725. doi:10.1007/s00595-007-3706-2
Peake, J., Gatta, P. D., & Cameron-Smith, D. (2010). Aging and its effects on inflammation in skeletal muscle at rest and following exercise-induced muscle injury. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 298(6), R1485-R1495.
Hsieh, M.-J., Liu, H.-T., Wang, C.-N., Huang, H.-Y., Lin, Y., Ko, Y.-S., Wang, J.-S., Chang, V. H.-S., & Pang, J.-H. S. (2016). Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. Journal of Molecular Medicine, 95(3), 323–333. https://doi.org/10.1007/s00109-016-1488-y
Alzaidi, S. S. (2009, November 19). Computational Models of Cerebral Hemodynamics. University of Canterbury. https://ir.canterbury.ac.nz/handle/10092/3159